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Search For New Therapeutic Agents Against Complicated Obesity

By Reprofiling Existing Drugs

 
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The final goal of the project is to generate two types of biomedical products, cytomic biomarkers of complicated obesity measured in ex-vivo samples, and candidates for new indications of existing drugs suitable for progressing towards clinical trials for the treatment and prevention of complicated obesity. The research, technological development and innovation activities have been broken down into two blocks of work and 9 work packages (WP):

 Reprobesity Pert Diagram

WORKBLOCKS

Workblock A: Reprofiling drugs targeting the abdominal adipose tissue (Workpackages 1 to 3)

Workblock B: Combinatorial Cytomic Biomarkers of obesity in fresh whole blood and abdominal adipocytes (Workpackages 4 to 6)

 

WORKPACKAGES

WP 1 Reprofiling drugs targetting adipose tissue function 

WP 2 Validation of candidates on in vivo animal models

WP 3 Identification of mechanism of action of candidates

WP 4 Identification of whole-blood cytomic biomarkers for obesity and its complications in animal models

WP 5 Validation of cytomic biomarkers in normal humans obese patients

WP 6 Functional significance of obesity biomarkers 

WP 7 Integrating biomarkers and therapeutics in obesity

WP 8 Communication and Dissemination

WP 9 Coordination activities MGT 1 1 36 Reprofiling drugs targeting the abdominal adipose tissue (Workpackages 1 to 3)

Last Updated on Tuesday, 16 June 2009 10:25